Course Instructor:
Vida Praitis
Email: praitis@grinnell.edu
Office: 1203
Phone: X4390
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Axis Specification
| Week 1. | Anterior-posterior axis determination
in Drosophila (1/25) Gilbert, Developmental Biology: 6th Edition. p. 263-290. Nusslein-Volhard C, Wieschaus E. Nature. 1980 287(5785):795-801. Driever W, Nusslein-Volhard C. Cell 1988 Jul 1;54(1):95-104 |
| Week 2. | Dorsal Vental patterning:
The role of DPP in Drosophila (2/1) Gilbert p. 290-302. Anderson KV, Nusslein-Volhard C., 1984. Nature 311(5983):223-7. Nusslein-Volhard C, et al, 1980. Nature 283(5746):474-6 Entchev, 2000. Cell 103:981-991. |
| Week 3. | Cell Fate changes in C. elegans:
glp-1/notch in early cell fate (2/8) Gilbert p. 251-257. Early cell fate decisions in C. elegans Gilbert p. 143-170. Cell-cell signaling Mello, et al, 1994. Cell 77:95-106. Mango, et al, 1994. Development, 120:2305-2315. |
| Week 4. | Mesoderm in C. elegans: WNT
Signalling (2/15) Gilbert p. 251-257. Review: Han 1997. Cell 90:581-4. Goldstein 1992 Nature 357:255-58. Thorpe, 1997. Cell 90:695-705 Rocheleau, 1997 Cell 90:707-716. |
| Week 5. | Axis in Vertebrates: Nieuwkoop
center & b-catenin (2/22) Gilbert, Ch. 10 p. 303-335 Larabell, et al, 1997. J. of Cell Biol 136:1123-36. |
| Week 6. | Spemann Organizer & DPP.
Evolution: Flies are like frogs (3/1) Gilbert p. 152-153 Zimmerman, etal Cell 86:599-606. Holley SA, etal. Cell. 1996 Aug 23;86(4):607-17. |
Creation of Tissues
| Week 7. | Signal transduction pathways:
vulva morphogenesis (3/8) Gilbert p. 143-170. Cell-cell signaling. Han & Sternberg, 1990. Cell 63:921-931. Kenyon, 1995. Cell 82:171-174 (review). Katz, et al, Cell 82:297-307 |
| Week 8. | Transcription factors, Pax6
and Eye development (3/15) Gilbert, p. 116-122. Review trnx factors, Pax-6. Gilbert, p. 399-403. Eye Development. Gilbert, p. 93-95. Pax-6 gene expression. Halder, Callaerts, and Gehring, 1995. Science 267:1788-92. Chow, et al, 1999. Development 126:423-4222. |
| Two Week Break | |
| Week 9. | The coordination of signals:
making Limbs (4/5) Gilbert, p. 503-522. Johnson and Tabin, 1997. Cell 90:979-990. Review Vogt,1999. Cell 99:563-566. Review Kawakami, et al, Cell 104:891-900. Hartmann and Tabin, 2001. Cell 104:341-51. |
Sex
| Week 10 | Establishment of the Germline
(4/12) Gilbert, p. 586-595 Review: Wylie, 1999. Cell 96:165-174 Jongens, Hay, Jan & Jan, 1992. Cell 70:569-584. Germ cell less/Dros. Subramaniam and Seydoux, 1999. Development 126:4861-4871 Tenenhaus C, et.al., 2001. Genes Dev.;15:1031-40. Mello, et al 1992 Cell 70:163-176 Mello, et al 1996. Nature 382, 710-712. |
| Week 11 | Sex Determination (4/19) Gilbert p. 523-543 Review Meyer 2000, TIG 16:247-253 Carmi I, Meyer BJ. Genetics. 1999 Jul;152(3):999-1015. |
| Week 12 | Dosage Compensation/X inactivation
(4/26) Gilbert p.125-130 Lyon, Mary, 1961. Nature 190:372-373 Heard et al 2001 Cell 107:727-738 Lee and Lu, 1999 Cell 99:47-57 |
| Week 13 | Fertilization (5/3) Review Wassarman, 1999. Cell 96:175-183. Gilbert, Ch. 7, p. 185-221. Primary Paper TBA |
| Week 14 | Battle of the Sexes: Genomic
Imprinting (5/10) Gilbert p. 126, p. 213. Ridley, Matt 1999. Genome: The autobiography of a species in 23 chapters. Chapter X. |
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