HUMAN VARIATION ANT 295.01 – FALL 2003 V. Bentley-Condit bentleyc@grinnell.edu Ext. 4305 Office Hrs: T,Th 1p-4p
DESCRIPTION: In this course, we will examine human genetics, differentiation, and variation – both between and within human groups. Topics of discussion include: the basics of human genetics, population genetics, gene frequencies, inheritance and heritability, genetics and disease, genetics and IQ, race, gene therapy and designer babies, cloning, and the Human Genome Project. The first part of the course will consist of a review of human evolutionary history (the fossil record), the basic principles of molecular and Mendelian genetics, and Darwinian evolutionary theory. In the second part of the course, we will examine genetic based diseases, disorders, and anomalies. Finally, we will focus on issues such as race, IQ, and the impact of genetic engineering and technology upon current and future humans.
COURSE MATERIALS: 1) Hawley, R.S. & Mori, C.A. 1999. The Human Genome: A User’s Guide. Academic Press, San Diego. (H&M) 2) Molnar, S. 2002. Human Variation: Races, Types, and Ethnic Groups, 5^th ed. Prentice Hall, New Jersey. 3) Cavalli-Sforza, L. 2000. Genes, Peoples & Languages. University of CA Press. 4) Other readings and materials as assigned.
COURSE REQUIREMENTS: 1) Exams – 3 @ 25% - There will be three in-class exams, each covering approx. 1/3 of the course. 2) Problem Sets – 14% - Seven problem-sets will be assigned throughout the semester that re-emphasize the readings. They will be due in class on Mondays and will not be accepted late. 3) Attendance & Participation – 11%: These are mandatory and I keep track of both. If you’re not planning on attending and participating in every class, you’re wasting your time and mine.
WEEK/DATES	TOPIC(S)	ASSIGNMENT(S)
WK 0 F – 29AUG	Preliminaries	Find a major newspaper or news source online and see what aspects of genetics are making current headlines. Bring to class.
WK 1 M – 01SEP W – 03SEP F – 05SEP	Evolutionary Theory Darwinian Evolution Non-Darwinian Evolution and The Modern Synthesis Evolution Since Darwin	RR1:Goldsmith & Zimmerman, CH 2, Charles Darwin and … RR2: Goldsmith & Zimmerman, CH 4-5, Genetic Continuity… and After Darwin:… RR3: Goldsmith & Zimmerman, CH 6, Evolutionary Social …
WK 2 M – 08SEP W – 10SEP F – 12SEP	Human Evolutionary History Australopithecines & Early Homo Homo erectus through archaic Homo sapiens Modern Homo sapiens	RR4: Boyd & Silk, CH 11, The Earliest Hominids; Problem Set 1 Due RR5: Boyd & Silk, CH 13, The Ancients RR6: Boyd & Silk, CH 14, The Moderns
WK 3 M – 15SEP W – 17SEP F – 19SEP	The Basics of Heredity Genes & Mendel Genes & Mendel How Genes Work	H&M 1 H&M 2 H&M 3
WK 4 M – 22SEP W – 24SEP F – 26SEP	How Genes Move Mutations & Phenotype Sex & Chromosomes	H&M 4; Problem Set 2 Due H&M 5 H&M 6,7
WK 5 M – 29SEP W – 01OCT F – 03OCT	Genetics, Disorders, Behavior Gender Imprinting & Turner Syndrome Review/Catch-up	H&M 8; Problem Set 3 Due H&M 11 N/A
WK 6 M – 06OCT W – 08OCT F – 10OCT	EXAM 1 (Through 26SEP) Down Syndrome Huntington Disease	N/A H&M 9 H&M 10
WK 7 M – 13OCT W – 15OCT F – 17OCT	Cystic Fibrosis Muscular Dystrophy Cancer	H&M 15; Problem Set 4 Due; http://www.phd.msu.edu/DNA/cf_fam.pdf H&M 16 H&M 17
WK 8 M – 27OCT W – 29OCT F – 31OCT	Mental Illness Criminality AIDS	H&M 18; Problem Set 5 Due H&M 19 H&M 20
WK 9 M – 03NOV W – 05NOV F – 07NOV	Sickle Cell Genetics, Intelligence, Race, & Variation Genes, Race, & History Review/Catch-up	Molnar 4; Problem Set 6 Due C-F 1 N/A
WK 10 M – 10NOV W – 12NOV F – 14NOV	EXAM 2 (Through 03NOV) Modern Human Populations Racial Variation	N/A C-F 3 ; Wallace, Using Maternal & Paternal Genes… pp 131-146 (http://books.nap.edu/books/0309074363/html/index.html) Molnar 1
WK 11 M – 17NOV W – 19NOV F – 21NOV	Blood Groups, Etc. Height, Skin color, Etc. Breeding Populations & Gene Geography	Molnar 3 ; C-F 2 Molnar 5  Molnar 6; C-F 4
WK 12 M – 24NOV W – 26NOV	Demographic Trends Intelligence	Molnar 8 RR 7: Ridley, Chromosome 6. Intelligence; Molnar 7
WK 13 M – 01DEC W – 03DEC F – 05DEC	Language & Culture Genomics Cloning Human Gene Mapping	C-F 5,6 H&M 12 H&M 13,14; DNA profiling – read and work through the Blackett Family DNA Activity and Activity 2 at http://www.biology.arizona.edu/human_bio/human_bio.html . Note that you do not have to do the problems with Activity 2 but could find it useful to try.
WK 14 M – 08DEC W – 10DEC F – 12DEC	Pre-Natal Diagnosis & Gene Therapy Eugenics, Human Rights, & Genetic Enhancement Wrap-up/Catch-up/Review	H&M 21, 22; Problem Set 7 Due Kevles, Eugenics, the Genome, and Human Rights, pp 147-154 Rothman & Rothman, Redesigning the Self , pp 155- 164 (http://books.nap.edu/books/0309074363/html/index.html) N/A
WK 15 W- 17DEC – 9am	EXAM 3 (Beginning 05NOV)	N/A

RESERVED READINGS BIBLIOGRAPHY

1) Goldsmith, T.; Zimmerman, W. 2001. Biology, Evolution, and Human Nature. New York: John Wiley & Sons. CH 2, Charles Darwin and the Origins of Evolutionary Theory, pp. 21-51.

2) Goldsmith, T.; Zimmerman, W. 2001. Biology, Evolution, and Human Nature. New York: John Wiley & Sons. CH 4, Genetic Continuity and Change: Organisms, Environments, and Microevolution and CH5, After Darwin: Molecular Evolution, Selection, and Adaptation, pp. 85-124.

3) Goldsmith, T.; Zimmerman, W. 2001. Biology, Evolution, and Human Nature. New York: John Wiley & Sons. CH 6, Evolutionary Social Theory, pp. 125-154.

4) Boyd, R.; Silk, J. 2000. How Humans Evolved, 2^nd ed. New York: W.W. Norton & Company. CH 11, The Earliest Hominids, pp. 326-374.

5) Boyd, R.; Silk, J. 2000. How Humans Evolved, 2^nd ed. New York: W.W. Norton & Company. CH 13, The Ancients, pp. 408-451.

6) Boyd, R.; Silk, J. 2000. How Humans Evolved, 2^nd ed. New York: W.W. Norton & Company. CH 14, The Moderns, pp. 452-488.

7) Ridley, M. 2000. Genome: The Autobiography of a Species in 23 Chapters. New York: Harper Collins. Chromosome 6: Intelligence, pp. 76-90.